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* alkalosis and steroids
 #139524  
  apple06 - 11/18/06 09:23
 
  Hi! COuld anyone tell me why exogenous or endogenous (Cushing's disease) steroids cause alkalosis? I'd really appreciate the help. Thanks!  
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* Re:alkalosis and steroids
#563637
  malev - 11/18/06 12:45
 
  well, as u know in cushings disease there is excess glucocorticoids.there is also an increased mineralocorticoid actions due to this.so as we know when there is inc aldosterone there is inc loss of potassium.its HYPOKALEMIC ALKALOSIS. as there is loss of H+ ions also.
in 2 words.when inc K+ ions in lumen of renal tubules there will be a movement of H+ ions also in to the lumen of tubules ,thus leading to it loss.
hope u undestood.
 
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