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* interesting q
  dolly123 - 11/07/06 22:34
  A 20-year-old man is scheduled to undergo vascular surgery in 1 week and is expected to suffer a significant amount of blood loss. The patient has a rare blood type and there is a national shortage of blood supply. Two of the patient’s family members share the same blood type and wish to make a targeted donation. After discussing possibilities of transfusion risks, the family wishes to proceed with the donation. Which of the following procedures would be most effective in minimizing transfusion risks?

A. Filter the blood
B. Premedicate with acetaminophen and diphenhydramine
C. Treat the blood with gamma irradiation
D. Treat the blood with ultraviolet irradiation
E. Wash the blood
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* answer...since im signing off for now
  dolly123 - 11/07/06 22:35
  The correct answer is C. Leukocytes in the blood mediate graft-versus-host disease (GVHD) and are a severe risk for transfusion reaction. Gamma irradiation effectively eliminates the lymphocytes and prevents the reaction.

Filtration (choice A) does not remove an adequate number of leukocytes. It could remove air bubbles that may cause embolic episodes.

Premedication with acetaminophen and diphenhydramine (choice B) often is done before routine blood transfusions to avoid an allergic reaction and may be done in this case also. The patient is at increased risk for GVHD because he will get blood from relatives, however, and the gamma radiation is necessary.

Ultraviolet radiation (choice D) is an experimental procedure and not the standard of care.

Similarly, washing the blood (choice E) is not as effective in removing leukocytes
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