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* Crazy 3
  shinenrise - 12/06/17 12:38
  A 53-year-old man with a known history of hypertension comes to the emergency department with shortness of breath and chest tightness. The patient was playing in a poker tournament when his symptoms first began. He has a history of hypertension and is not compliant with his medications. His last medical follow-up was a year ago. Blood pressure is 195/115 mm Hg and pulse is 90/min and regular. Lung examination reveals bibasilar crackles. Nitroglycerin infusion is started and results in significant symptomatic improvement. Repeat blood pressure is 165/90 mm Hg. Which of the following intracellular events is most likely responsible for the beneficial effects of this patientís treatment?

A. Actin phosphorylation
B. Calcium release from sarcoplasmic reticulum
C. Enhanced cyclic mononucleotide degradation
D. Inositol triphosphate accumulation
E. Myosin dephosphorylation
F. Tyrosine kinase activation
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* Re:Crazy 3
  anasteps - 12/06/17 19:33

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* Re:Crazy 3
  sawtooth - 12/06/17 19:42
  Ans. E. SMR . NO.

Nitrates stimulate NO simulating Guanyly cylase. Hence coverting GTP to cGMP.
CGMP causes Myosin light chain dephosphorylation causes relaxation
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* Re:Crazy 3
  shinenrise - 12/07/17 01:49
  Correct E  
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* Re:Crazy 3
  halux - 12/07/17 09:02
  excellent explanation @sawtooth
keep it up!!!!!
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