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* Job syndrome due to Th1 defect or TH17?
 #847828  
  beth1 - 02/04/18 03:36
 
  Kaplan says "TH1 cells cannot make IFN-y"
FA: Deficiency of Th17 cells due to STAT3 mutation -- > impaired recruitment of neutrophils to sites of infection.
 
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* Re:Job syndrome due to Th1 defect or TH17?
#3360592
  beth1 - 02/12/18 17:17
 
  ??  
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* Re:Job syndrome due to Th1 defect or TH17?
#3360610
  cardio69 - 02/12/18 18:14
 
  That would be inherited condition Job’s defect in Th17 cell respond. STAT3 key role dif of a virgin Tcell -> IL-17 producing CD4 /Th17 ( as u know come to pic in fungal & extracellular bug ). So, if failure IL-17 production abnorm probably also effects the pathways leading to IFN-g production in pat with AD since the mononuclear cells of these pat produce ↓ amounts of IFN-g upon that tickling. On lab u see ↑IgE and going down in INF-g.
Now, T cell defect also been reported that def in producing INF-g & TNF-a -> ↓ # CD8 memory T cell and diminish DTH & lymphoproliferative responses to Ag tickling.

Know FA one cold.
 
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* Re:Job syndrome due to Th1 defect or TH17?
#3360619
  beth1 - 02/12/18 18:33
 
 
the STAT3/TH17 connection is clear to me
the decreased IFN-g is by TH1 cells defect?
Now i understand that the increased IgE is due to the imbalanced TH1/TH2 in favor of TH2(IL-4 for IgE)
Thank you cardio69
 
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* Re:Job syndrome due to Th1 defect or TH17?
#3360715
  yousmle99 - 02/13/18 17:37
 
  Beth1- it's no longer called job's syndrome ,Its new name is Hyperimmunoglobulin E syndrome.(HIES).

if you check 2017 kaplan they have corrected --> from TH1 cell defect to-------> "STAT3 defect"-->reduced TH17-->reduced IFN-g----> decreased TH1 response and reduced inhibitory effect on TH2 lineage b/c -->unopposed/uninhibited IL-4(by IFN-g)--> high IgE.

FA is called usmle bible for a reason (:
 
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