a 3 year old girl is brought to emergency room unconcious after ingesting unknown amount of ethanol, her serum glucose conc is 30 mg/dl. through which of the following mechanism, are the products of alcohol metabolism contribute to hypoglycemia ?
1. Increasing the conversion of pyruave to oxaloacetate
2. increasing the formation of pyruavte from acetyl CoA
3. Increasing the reduction of pyruvate to lactate
4. Inhibiting pyruvate dehydrogenase
5. Inhibiting the formation of pyruvate from lactate
Plz . explain yr answer ....
answer is 3. High NADH level from ethanol metabolism will favor reduction of pyruvate into lactate to regenerate NAD+. Correct me if I'm wrong
yes answer is 3. I overlooked the question. Thanks lostinprep.
I think choice 4 is mechanism of hypoxia.
yeh, the ans is 3 .... as explained by lostinprep ...
the answer is 5. Inhibiting the formation of pyruvate from lactate
ALCOHOL>>decrease NAD >>>decrease pyruvate CONVERSION FROM LACTATE >>>decrease pyruvate >>>decrease gluconeogenesis>>>hypoglycemia
super99, the ans is 3 ....high NADH in hepatocytes after alcohol consumption, favors the following reactions ....
1. the pyruvate which is supposed to be converted to glucose, is converted to lactate, so no gluconeogenesis
2. DHAP is directed to glycerol 3 p, so no gluconeogenesis
3. OAA is converted back to malate in the cytoplasm after malate shuttle (normally malate is converted to OAA in cytoplasm which in turn is converted to PEP), so no gluconeogenesis
yes 3 is the answer as well explained by usmleblockbuster and others(check first aid 2008 pg 80 for more infos.
High amounts of cytoplasmic NADH is produced via alcohol dehydrogenase and acetaldehyde dehydrogenase (alcohol metabolism) → Interference of GLUCONEOGENESIS
↑↑↑ NADH:
(+) pyruvate→Lactate
(+) Malate from OAA
(+) Glycerol 3-P from DHAP → FATTY LIVER!!!