can we give it in a 28 yr old lady with steady sexual relation with hep C, liver bx showing florid inflammation?
can u add more explanation...
atleast moderate inflamation must treat with riba+interferon+ hep.a vaccine
ok, lady is 28 yr old, sexually active with single partner, using condoms, having chronic active hep C, liver bx shows florid inflammation. now can we give ribavirin? p-inf already given.
ribavirin is teratogenic so it needs atleast 2 form of contraception like retinoic acid and have to check upt .
yes, so after 2 forms of contraceptive, what advice should be given regarding getting pregnant after tx completion wid ribavirin?
not to get pregnant for 3 months?
Significant teratogenic and/or embryocidal effects have been demonstrated in all animal species exposed to Ribavirin. In addition, Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months. Ribavirin therapy is contraindicated in women who are pregnant and in the male partners of women who are pregnant. Extreme care must be taken to avoid pregnancy during therapy and for 6 months after completion of therapy in both female patients and in female partners of male patients who are taking Ribavirin therapy. At least two reliable forms of effective contraception must be utilized during treatment and during the 6-month posttreatment follow-up period
gr8 guys. nimish explained it. thanks.