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Pt on insulin requires large doses & gradually becoming less responsive to insulin -->Next best step ?

change the type of insulin?

Note: This pt is developing Insulin resistance.

add glitazone as next step?

yes add metformin/ thiazolidinedione (to decreases insulin resistance)

Pancreatic Beta cell transpant from (Adults Stem Cells) (Regenerative medicine) not asked in step 3....

Harry dear, name 2 drugs (antiDM ) which keeps weight static or even reduces little bit?

Drugs causing wt loss/wt static:-

(a) Amylin Analogs (Pramlintide)
(b) GLP-1 agonist (Exenatide)
© Biguanides (Metformin)
(d) DDP-IV inhibitors (Sitagliptin, Vildagliptin) -->(coming soon in market)

Guest dear, name 2 antiDM drugs C/I in pt with advanced heart failure.

i knew b,c . man, dont have idea about futuristic drugs. thanks .