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How it cause upper motor defect in lower limb & lower motor defect in upper limb at the same time ? Pl anybody explain . Thanks a lot

it affects both the ventral horn and corticospinal tracts - thus due to ventral horn , you get lmn, due to corticospinal tract lesion- you get umn

cookie86 thanks .appeciate it

is anterior horn and ventral horn the same thing?
because from DIT, i heard that ALS causes damage to the anterior horn and corticospinal tract

thanks