01-23-2012, 03:22 PM
A 25-year-old man is evaluated for a 6-month history of eight loose, nonbloody stools a day; he also has abdominal pain and small-joint arthritis. The patient has a 5-year history of Crohn disease, initially treated with corticosteroids but then maintained on azathioprine therapy. Small-bowel radiographic series shows no stricturing disease but some active jejuno-ileitis. Azathioprine metabolites were recently measured and were found to be at therapeutic concentration.
Which of the following is the most appropriate additional therapy for this patient?
A 5-Aminosalicylate
B Anti-tumor necrosis factor α-inhibitor
C Calcineurin inhibitor
D Corticosteroids
Which of the following is the most appropriate additional therapy for this patient?
A 5-Aminosalicylate
B Anti-tumor necrosis factor α-inhibitor
C Calcineurin inhibitor
D Corticosteroids