I am really confused with these terms: FDP and D dimers...
In primary fibrinolysis (open heart surgery) why is there increase in FDP but no increase in D dimers???
Plasmin cleaves fibrin at multiple sites and releases fibrin degradation products (FDPs). One of the major FDPs is D-dimer, which consists of two D domains from adjacent fibrin monomers that have been crosslinked by activated factor XIII.
Since D-dimer is generated from cross-linked fibrin, but not from fibrinogen, an elevated plasma concentration of D-dimer indicates recent or ongoing intravascular blood coagulation.
Well explained, thanx nader_s