01-29-2006, 03:04 PM
do they both present with cushing? since ACTH is high, and cortisol low? also do they both cause hyperpigmentation? how can you really distinghuish one from the other?
thanks in advance
thanks in advance
01-29-2006, 03:04 PM
01-29-2006, 05:01 PM
what i think is with Addison problem is in adrenal cortex ( thus low cortisol) , low cortisol causes positive feedback to increase pituitary secretion of ACTH. In pit adenoma problem is at pituitary ( excess pdtion of ACTH) which causes causes increased cortisol. Cushing occurs in hypercortisolism thus in pit adenoma, but not in addison.
In addison there is hyperpigmentation ( aka Nelson syndrome) because the excess ACTH pdtion which has similar sequence to melanocyte stimulating hormone.
Not sure if same occurs in pit adenoma
In addison there is hyperpigmentation ( aka Nelson syndrome) because the excess ACTH pdtion which has similar sequence to melanocyte stimulating hormone.
Not sure if same occurs in pit adenoma
01-29-2006, 05:07 PM
thank you, yes I can see that better now =)