Actually I am confused ,can anybody tell me where can I read the mechanism of drug resistance?
thanks
hi mdkhayat just remember the mechanism of action every step clearly...i think its given in uworld and first aid is also good ....of course kaplan LN but now no time ..
try to remember the picture or figures given in first aid that should help
ok ,I need to know which resistant mechanism for which MO.
lets start ,please write what you know ,all my friends ,
1. Vanco resistant staph aureus :
2.Methicillin resistant staph aureus
3.beta lactamase resistant
4. meropenem resistancy
5.chloramphenicol resistancy
6.macrolid resistancy
7......
please answer what you know and add what other you know
thanks
1.vancomycin resistance to satph.aureus is through transposition van A gene from enterococcus but generally bacteria develop resisitance by altering d-ala-d-ala aminoacid to d-ala-d-lac
2.MRSA is by structural change in penicillin binding proteins
3 and 4..carbpenems also same as cephalosporins and penicillins structural change in PBP(transpeptidases)
5 ..MOA - binds to ribosomal 50s and inhibit peptidyl transferase enzyme right ....resistance is by plasmid encoded acetytransferase inactivates the drug
6. MARCOLIDES- formation of methyltransferases that alters drug binding sites(methylation of 23 rRNA binding site)