08-11-2017, 10:05 AM
MOBILE POOL: Indirect acting sypathomimetics (e.g. amphetamines, ephedrine, tyramine) displace NE , enhancing postjunctional actions.
UPTAKE 1: Inhibited by some Indirect-acting sympathomimetics (e.g. cocaine). Increasing postjunctional actions of NE.
Prejunctional Alpha Receptor (ALPHA 2):Activators (e.g clonidine alpha metyldopa) cause inhibition of tyrosine hydroxylase (↓ NE release from ending)
GRANULAR UPTAKE of NE: Blocker (e.g. reserpine) decrease prejunctional levels of NE available for release.
NE release from Granules: Blocker (e.g guanethidine) decrease postjunctional acions of NE.
Postjunctional Receptors: Activated by many direct-acting sympathomimetics and are also" targets" for antagonist drugs.
UPTAKE 1: Inhibited by some Indirect-acting sympathomimetics (e.g. cocaine). Increasing postjunctional actions of NE.
Prejunctional Alpha Receptor (ALPHA 2):Activators (e.g clonidine alpha metyldopa) cause inhibition of tyrosine hydroxylase (↓ NE release from ending)
GRANULAR UPTAKE of NE: Blocker (e.g. reserpine) decrease prejunctional levels of NE available for release.
NE release from Granules: Blocker (e.g guanethidine) decrease postjunctional acions of NE.
Postjunctional Receptors: Activated by many direct-acting sympathomimetics and are also" targets" for antagonist drugs.