Cl Resistant vs Chloride Sensitive M. Alkalosis - ben - Printable Version +- USMLE Forum - Largest USMLE Community (https://www.usmleforum.com) +-- Forum: USMLE Forum (https://www.usmleforum.com/forumdisplay.php?fid=1) +--- Forum: Step 3 (https://www.usmleforum.com/forumdisplay.php?fid=6) +--- Thread: Cl Resistant vs Chloride Sensitive M. Alkalosis - ben (/showthread.php?tid=128030) |
Cl Resistant vs Chloride Sensitive M. Alkalosis - ben - ArchivalUser - 10-13-2006 Could somone expl this concept. 1. Pls Explain what this means restistance vs sensitive CL M Acidosis. (What is the cause of high or low urinary CL??) 2. Which lab values tell syou if it is Cl resistant or sensitive (serum or urinary Cl levels) thx 0 - ArchivalUser - 10-13-2006 its metabolic alkalosisi which is cl sesitive and resistant . e.g in vomiting u lose ur HCL , so u have to replace with Nacl( vomiting respond to cl replacement ) urinary cl is >20. while in hyperaldostetonism urinary cl is >20, , treat it with spiranolactone - we check chloride in urine guys correct me if i am wrong 0 - ArchivalUser - 10-13-2006 Ok Pls confrim this to see if i understood this rite In Cl responsive 1.Vomit ---CL lost in vomit => low Cl levels are sensed in Kidney and that activates ren-ang-aldost, which in turn => incr NaCl reabs. & K/H secrtion =>urinary Cl low. 2.Thiazide diurectics ---inhibt cotransport of Na/CL and again => incr delivery to distal duct plus the hypovolemia cause renin-ang-aldost....=> urinary Cl high In Cl resistant 1. Barter --Na/K/Cl cotrans imp absorbt., also loose ca into urine ==> incr delivery again to distal collect ==> activate reni-ang-aldost = > incr NaCl at distal collect duct and excrete K/H but why is this called resistant, b/c even in Barters we end up reabs NaCl thru aldost activation?? Can u guys confrim?? 0 - ArchivalUser - 10-13-2006 lala, anyone have a comment, ajeet maybe you can shed some light |