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+--- Thread: heparan sulfate - abrahem (/showthread.php?tid=150331)
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heparan sulfate - abrahem - ArchivalUser - 01-05-2007
which compound of skin play the same function of heparan sulfate in kidney?
proteoglycan or collagen IV?
or any other one?
0 - ArchivalUser - 01-05-2007
i think collagen IV.. basement membrane
0 - ArchivalUser - 01-06-2007
Skin already has its own type IV collagen. heparan sulfate is one type of proteoglycan, also exist in skin. that's what I know.
0 - ArchivalUser - 01-06-2007
what bout dermatan sulfate?
0 - ArchivalUser - 01-06-2007
what is the function of heparan sulfate in kidney? then we can figure out what the answer
0 - ArchivalUser - 01-06-2007
the negative charge of heparan sulfate can prevent prooteinuria
0 - ArchivalUser - 01-06-2007
and also loss of other ions
so what compound of skin that prevent ions loss?
0 - ArchivalUser - 01-06-2007
I believe the Glomerular Basement Membrane is very unique in the body. It forms filtration barrier together with endothelial and slit diphragm of podocyte. Would you like to share the whole question?
0 - ArchivalUser - 01-06-2007
the whole question is bla bla....... and then at the end: what the compound of skin that prevent ions loss?
i know that heparan sulfat prevent ions loss in kidney so i made this question as copmare to kidney
0 - ArchivalUser - 01-06-2007
why heparan sulfate prevent the loss of ion? in fact, the crude urine in the beginning of proximal tubular is osmotically equal to that of plasma, right?
As for your Q, first prevention of loss of ion in skin has two aspects: one is the cap in skin, and other is gland.
for the carpillary in skin that is different from the cap that compose Glomerular, there is bigger hole between the endothelials of cap in Glomerular than that in skin. while the ion can get out of the vessle easily, but protein can not. You can imagine the concept isoosmotic and isotonic.
For the sweat gland, how to understand the keep and loss of ion through sweat gland, just think of the mechanism underlysing CF, then you will get it.