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+--- Thread: toxic q - math3 (/showthread.php?tid=159596)
toxic q - math3 - ArchivalUser - 02-07-2007
8-36. A 45-year-old male with alcoholic cirrhosis is seen in the ED
because of a laceration of the scalp. Of the following local anesthetics,
which would potentially be toxic?
a. Lidocaine
b. Benzocaine
c. Procaine
d. Tetracaine
0 - ArchivalUser - 02-07-2007
aaa??
0 - ArchivalUser - 02-07-2007
A. Lidocaine
0 - ArchivalUser - 02-07-2007
lidocaine
0 - ArchivalUser - 02-07-2007
right lidocaine
0 - ArchivalUser - 02-07-2007
please post explanations for your Q if you have them...thanks
0 - ArchivalUser - 02-07-2007
poor liver function (cirrhosis ) are unable to biotransform amide
0 - ArchivalUser - 02-07-2007
8-36. The answer is a. (Hardman, p 338. Katzung, pp 438“439.) Ester-type
local anesthetics are mainly hydrolyzed by pseudocholinesterases. Amidetype
local anesthetics are hydrolyzed by microsomal enzymes in the liver. Of
the listed agents, only lidocaine is an amide and can be influenced by liver
dysfunction.