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+--- Thread: regarding the ati cancer drugs. - jesh (/showthread.php?tid=253707)
regarding the ati cancer drugs. - jesh - ArchivalUser - 12-20-2007
can any one please give me the list of drugs which are cell cycle specific
0 - ArchivalUser - 12-20-2007
I don't have the complete list: but some include vincristine, 5-Floro uracil, etopoxide, taxels (doxitaxel), hydroxyurea.....
0 - ArchivalUser - 12-20-2007
thanks, but i would like to knew,that all these drugs are acting in which phases of cell cycle.
0 - ArchivalUser - 12-20-2007
Jesh, here are the specific phases in w/c they act:
Antimetabolites (e.g. 5 Flourouracil)...............................S
Alkaloids (e.g. Doxorubucin, ActinomycinD)....................S and M
Vincristine...................................................................M
Topo inhibitors (e.g. Etopoxide).....................................S
Taxanes (e.g. Docetaxel)..............................................M
Hydroxyurea ..............................................................?S (not well known)
Az
0 - ArchivalUser - 12-20-2007
thanks for ur response.
0 - ArchivalUser - 12-20-2007
bleomycin acts in G2 phase
0 - ArchivalUser - 12-20-2007
etoposide acts on both G2 and S phase.
correct me if i am wrong.
0 - ArchivalUser - 12-20-2007
Ya, makes sense.
In G2,cells are transcriptionaly active and need the Topo II to deal with changing topology during the process.
But I think cells need it more during S phase, that may be why thy put it under S-specific.