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+--- Thread: Anti cancer drugs acting in S phase - raji_321 (/showthread.php?tid=261380)
Anti cancer drugs acting in S phase - raji_321 - ArchivalUser - 01-16-2008
methotrexate- inhibits dihydrofolate reductase
mercaptopurine and thioguanine (both purine analogues that inhibit purine synthesis),
azacytidine (limits pyrimidine synthesis by inhibiting orotidylate decarboxylase),
hydroxyurea (inhibits formation of deoxyribonucleotides from ribonucleotides),
5-fluorouracil (inhibits thymidylate synthase) and
cytarabine (AKA cytosine arabinoside, which inhibits DNA
polymerase).
any more??
0 - ArchivalUser - 01-16-2008
daunorubicin and doxorubicin.
0 - ArchivalUser - 01-16-2008
hi joannitam, both daunorubicin and doxorubicin are not mentioned in kaplan pharma under S phase..
so i browsed... it seems that these are cell cycle nonspecific drugs. explanation.. those that bind directly to DNA are not cell cycle specific
Duanorubicin & doxo (binds to and intercalates DNA, DNA strand breakage and inhibition of the enzyme topoisomerase II)
0 - ArchivalUser - 01-16-2008
other examples of cell cycle nonspecific drugs-- dactinomycin, mithramycin
0 - ArchivalUser - 01-16-2008
Etoposide is also S phase drug. ( eukaryotic topoismomerase inhibitor)