![]() |
Anti cancer drugs acting in S phase - raji_321 - Printable Version +- USMLE Forum - Largest USMLE Community (https://www.usmleforum.com) +-- Forum: USMLE Forum (https://www.usmleforum.com/forumdisplay.php?fid=1) +--- Forum: Step 1 (https://www.usmleforum.com/forumdisplay.php?fid=2) +--- Thread: Anti cancer drugs acting in S phase - raji_321 (/showthread.php?tid=261380) |
Anti cancer drugs acting in S phase - raji_321 - ArchivalUser - 01-16-2008 methotrexate- inhibits dihydrofolate reductase mercaptopurine and thioguanine (both purine analogues that inhibit purine synthesis), azacytidine (limits pyrimidine synthesis by inhibiting orotidylate decarboxylase), hydroxyurea (inhibits formation of deoxyribonucleotides from ribonucleotides), 5-fluorouracil (inhibits thymidylate synthase) and cytarabine (AKA cytosine arabinoside, which inhibits DNA polymerase). any more?? 0 - ArchivalUser - 01-16-2008 daunorubicin and doxorubicin. 0 - ArchivalUser - 01-16-2008 hi joannitam, both daunorubicin and doxorubicin are not mentioned in kaplan pharma under S phase.. so i browsed... it seems that these are cell cycle nonspecific drugs. explanation.. those that bind directly to DNA are not cell cycle specific Duanorubicin & doxo (binds to and intercalates DNA, DNA strand breakage and inhibition of the enzyme topoisomerase II) 0 - ArchivalUser - 01-16-2008 other examples of cell cycle nonspecific drugs-- dactinomycin, mithramycin 0 - ArchivalUser - 01-16-2008 Etoposide is also S phase drug. ( eukaryotic topoismomerase inhibitor) |