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qqqqq57 - ebnalfady - Printable Version +- USMLE Forum - Largest USMLE Community (https://www.usmleforum.com) +-- Forum: USMLE Forum (https://www.usmleforum.com/forumdisplay.php?fid=1) +--- Forum: Step 1 (https://www.usmleforum.com/forumdisplay.php?fid=2) +--- Thread: qqqqq57 - ebnalfady (/showthread.php?tid=275380) |
qqqqq57 - ebnalfady - ArchivalUser - 02-28-2008 Acute intermittent porphyria is a contraindication of the use of which of the following? A. Enflurane B. Nitrous oxide (N2O) C. Ketamine D. Diazepam E. Thiopental 0 - ArchivalUser - 02-28-2008 bb 0 - ArchivalUser - 02-28-2008 The answer is: E Induction of anesthesia by parenteral administration of thiopental sodium and other barbiturates is absolutely contraindicated in patients who have acute intermittent porphyria. These patients have a defect in regulation of -aminolevulinic acid synthetase; thus, administration of a barbiturate that increases this enzyme may cause a dangerous increase in levels of porphyrins. Administration of a barbiturate would exacerbate the symptoms of gastrointestinal and neurologic disturbances, cause extensive demyelination of peripheral and cranial nerves, and could lead to death |