immuno q8 - jcbc - Printable Version +- USMLE Forum - Largest USMLE Community (https://www.usmleforum.com) +-- Forum: USMLE Forum (https://www.usmleforum.com/forumdisplay.php?fid=1) +--- Forum: Step 1 (https://www.usmleforum.com/forumdisplay.php?fid=2) +--- Thread: immuno q8 - jcbc (/showthread.php?tid=294967) |
immuno q8 - jcbc - ArchivalUser - 04-21-2008 A 35-year-old male presents to an infectious disease specialist with recurrent infections with encapsulated bacterial organisms. The history indicates that these infections have become apparent in the last 6 months. Laboratory findings indicates that the total immunoglobulin level exceeded 900 mg/dL with a low CH50 (hemolytic complement) level. Which of the following is the correct diagnosis? A. Acquired hypogammaglobulinemia (common variable hypogammaglobulinemia) B. C3 deficiency C. Hyper-IgM syndrome D. Wiskott-Aldrich syndrome E. X-linked infantile hypogammaglobulinemia 0 - ArchivalUser - 04-21-2008 aa 0 - ArchivalUser - 04-21-2008 B??? 0 - ArchivalUser - 04-21-2008 bbb 0 - ArchivalUser - 04-21-2008 The correct answer is B. Individuals with C3 deficiency have an increased susceptibility to recurrent bacterial infections, especially with encapsulated bacteria. This susceptibility illustrates the important role of C3 as an opsonin. C3 deficiency is often not detected until later life. |