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+--- Thread: Q Thiamine deficiency - gusmle (/showthread.php?tid=521312)
Q Thiamine deficiency - gusmle - ArchivalUser - 07-25-2010
Q1- in order to assess Thiamine deficiency in an alcoholic patient , erythrocyte enzyme activity was assessed, what enzyme utilizes Thiamine as a cofactor?
Q-2 does any body know why some patients with thiamine deficiency presented by ( WET ) while the others have ( Dry ) beri beri ?????
0 - ArchivalUser - 07-25-2010
Q1-transketolase
Q2. I dont understand ur second q, I just know there is cardiac issues (wet), and peripheral neuropathy (dry)
0 - ArchivalUser - 07-25-2010
Q1- enz transketolase in HMP shunt
0 - ArchivalUser - 07-25-2010
Q 2 , if u have Thiamine deficiency, will u develop wet or dry type??
0 - ArchivalUser - 07-25-2010
you can develop either one or both
0 - ArchivalUser - 07-25-2010
Wet is due to lack of vit b1 in myocytes that is required for TCA cycle for energy generation..
no B1.. no energy generation and patient present with CHF thats wet beri beri..
and again in neurons vit B1 necessary for myelination.. no B1. no proper myelination.. and patient present with neuropathy.. dry beri..
0 - ArchivalUser - 07-25-2010
thanx yd