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+--- Thread: Try this - nilakash (/showthread.php?tid=584351)
Try this - nilakash - ArchivalUser - 05-06-2011
1.Hemochromatosis may result
a.restrictive cardiomyopathy
b.dilated cardiomyopathy
2. Freidrich's ataxia causes
a.hypertrophic cardiomyopathy
b.dilated cardiomyopathy
0 - ArchivalUser - 05-06-2011
1.a
2.a
0 - ArchivalUser - 05-06-2011
any other opinion?explanation?
0 - ArchivalUser - 05-06-2011
hemochromatosis can cause both
freidrichs ataxia causes hypertrophic cardiomyopathy
0 - ArchivalUser - 05-06-2011
Yes, 1: a and b
2/ a
0 - ArchivalUser - 05-06-2011
Ans:UWorld kept linking hemochromatosis to dilated cardiomyopathy in their explanation.
Goljan says it's restrictive cardiomyopathy. excess iron causes increased production of free radicals, which would cause fibrosis (thus resulting in restrictive cardiomyopathy, not dilated).
It's actually both.(for1 & 2). It starts off as restrictive and eventually enough Fe deposits to cause free radical damage to the mitochondria and mitochondrial damage is one of the initiating points in DCM. That's why people with friedrich's ataxia also get DCM b/c they have a mutation in the gene frataxin that affects integrity of mitochondria
http://en.wikipedia.org/wiki/Friedreich's_ataxia
0 - ArchivalUser - 05-06-2011
all restrictive cardiomyopathy eventually becomes DILATED, its the final common pathway for ALL cardiomyopathies.