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+--- Thread: Increased ammonia - dicky306 (/showthread.php?tid=631312)
Increased ammonia - dicky306 - ArchivalUser - 11-15-2011
Guys where in the Kaplan book is the explanation for increased NH3 as a side effect of acetozolamide given, someone told it's in. Kaplan but I can't find it anywhere , so if u do know where it is given specifically do tell
Thanks
0 - ArchivalUser - 11-15-2011
Dear friend,
In Kaplan, it's not clearly told why, but we can see it through mechanism of acetazolamide, inhibits carbonic anhydrase -> decreased ability to exchange Na+ for H+ -> HCO3 is retained in the lumen, with marked elevation in urinary pH
NH3 is a base
A base in a alkaline environment -> non ionized -> cross membrane and go into blood -> hyperammonia.
0 - ArchivalUser - 11-15-2011
Thanks a lot luckyluke