Molecular biology 1...Q - maryam2009 - Printable Version +- USMLE Forum - Largest USMLE Community (https://www.usmleforum.com) +-- Forum: USMLE Forum (https://www.usmleforum.com/forumdisplay.php?fid=1) +--- Forum: Step 1 (https://www.usmleforum.com/forumdisplay.php?fid=2) +--- Thread: Molecular biology 1...Q - maryam2009 (/showthread.php?tid=642338) |
Molecular biology 1...Q - maryam2009 - ArchivalUser - 12-23-2011 A researcher has designed a study in which she will compare the variability of alleles for two hundred genes on four chromosomes between two populations: two thousand children with low-functioning autism and two thousand children with no developmental or other disorder. Which tool will be the most useful for identifying allele variability? A.Allele-specific oligonucleotide probes B.DNA hybridization chips C.Small interfering RNA D.Restriction fragment length polymorphisms E.Variable number tandem repeats 0 - ArchivalUser - 12-23-2011 D 0 - ArchivalUser - 12-23-2011 dd 0 - ArchivalUser - 12-23-2011 AA ? 0 - ArchivalUser - 12-23-2011 EE??? Explain the answer plz.... 0 - ArchivalUser - 12-23-2011 The correct answer is D. Restriction fragment length polymorphisms.RFLP's are useful when a researcher is looking for genetic variabilty Allele-specific oligonucleotide probes (A) is used to identify a particular mutation,, or to count chromosomes. B is used to identify a set of single nucleotide polymorphisms.it’s most commonly used to measure gene expression in certain cells or tissues. siRNAs © would be used to modulate gene expression at the transcriptional/post-transcriptional level. VNTRs (E) are used for DNA fingerprinting 0 - ArchivalUser - 12-23-2011 ?? allele specific oligonucleotide probe 0 - ArchivalUser - 12-23-2011 thanks for the great question and explanation Your exam must be near Best of luck God bless you 0 - ArchivalUser - 12-23-2011 You are welcome Still working |