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+--- Thread: Question..............2 - psychmledr (/showthread.php?tid=676809)
Question..............2 - psychmledr - ArchivalUser - 05-13-2012
A 39-year-old male with aortic insufficiency and a history of no drug allergies is given an intravenous dose of antibiotic as a prophylaxis preceding the insertion of a valve prosthesis. As the antibiotic is being infused, the patient becomes flushed over most of his body.
What antibiotic was given?
A. Vancomycin
B. Gentamicin
C. Erythromycin
D. Penicillin G
E. Tetracycline
What is the mechanism?
0 - ArchivalUser - 05-13-2012
DDD Penicillin G?..vasovagal response ( vasodilation) its too early to cause any type of hypersensitivity at first exposure...pls answer..
0 - ArchivalUser - 05-13-2012
A??
vancomycin -- causes flushing... (Red man Syndrome)
0 - ArchivalUser - 05-13-2012
Vancomycin is right......how does it do that?
0 - ArchivalUser - 05-13-2012
vancomycin causes release of histamine...histamine syndrome ....but how does it cause histamine release ? if not by mast cell degranulation?...
0 - ArchivalUser - 05-13-2012
@icanhelpu:
Yes, it causes histamine release. But it is a non-Ig E-mediated reaction. It is a Direct action of vancomycin on mast cells and basophils.
It is also called an anaphylactoid reaction.
http://www.anesthesia-analgesia.org/content/97/5/1381/F1.expansion.html
0 - ArchivalUser - 05-13-2012
Other agents that can cause a similar reaction include OPIOIDS, DEXTRAN, and PROTAMINE.