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+--- Thread: Explanation please: Coagulation - all_mle (/showthread.php?tid=683006)
Explanation please: Coagulation - all_mle - ArchivalUser - 06-20-2012
I am really confused with these terms: FDP and D dimers...
In primary fibrinolysis (open heart surgery) why is there increase in FDP but no increase in D dimers???
0 - ArchivalUser - 06-20-2012
Plasmin cleaves fibrin at multiple sites and releases fibrin degradation products (FDPs). One of the major FDPs is D-dimer, which consists of two D domains from adjacent fibrin monomers that have been crosslinked by activated factor XIII.
Since D-dimer is generated from cross-linked fibrin, but not from fibrinogen, an elevated plasma concentration of D-dimer indicates recent or ongoing intravascular blood coagulation.
0 - ArchivalUser - 06-20-2012
Well explained, thanx nader_s