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Q. the frequency of homozygous - hunanliu - Printable Version +- USMLE Forum - Largest USMLE Community (https://www.usmleforum.com) +-- Forum: USMLE Forum (https://www.usmleforum.com/forumdisplay.php?fid=1) +--- Forum: Step 1 (https://www.usmleforum.com/forumdisplay.php?fid=2) +--- Thread: Q. the frequency of homozygous - hunanliu (/showthread.php?tid=72671) |
Q. the frequency of homozygous - hunanliu - ArchivalUser - 02-02-2006 In a Nigerian population, the frequency of males with G6PD deficiency is 0.2. Assuming the population is in Hardy-Weinberg equilibrium at this locus, what is the frequency of homozygous females? / A. 0.02 / B. 0.04 / C. 0.2 / D. 0.32 / E. 0.45 0 - ArchivalUser - 02-02-2006 Given that q=0.2, so q^2=0.04. 0 - ArchivalUser - 02-02-2006 hi calender you considered they are asking homozygous sick female right? what will the answer be if they mean homozygous female nl &sick? 0 - ArchivalUser - 02-02-2006 I thought they ask about homozygous mutation at that specific locus, don't they? That means, they are asking about frequency of diseased females. 0 - ArchivalUser - 02-02-2006 G6PD is an Xlinked recessive, so male is hemizygous for X chromosome. so male has only one copy of each trait, so the frequency of X linked recessive in males is equal to allel in the population. So q= 0.2 and p = 0.8. female has two copies of each geneon x chromosome, so equation for hardy weinberg equilibrium is same for autosomal traits. in this case homogygous recessive female would occur at a frequency of q square or 0.04. 0 - ArchivalUser - 02-03-2006 thanks calender,gl |