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+--- Thread: Q@Qdrug? - cardio69 (/showthread.php?tid=808350)
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Q@Qdrug? - cardio69 - ArchivalUser - 05-31-2015
A 44 y/o F presents to you with increasing morning stiffness and pain in her hands and fingers. She has severe tenderness over her proximal interphalangeal joints and has had difficulty using her hand due to pain. She has severe swan neck deformities and boutonniere of her hands. The woman also notes that she has had difficulty breathing and pain when she takes deep breath. Pat lab reveals neutrophil and lymphocyte within norm range and Hgb 9.8 g/dL. Pat fails to respond past 5mons triple therapy. You decide to add 4th drug that metabolite primarily CYP3A4 and ↓ IL-21 & 7 production on your pat. Name me the drug been added?
0 - ArchivalUser - 05-31-2015
Have no clue! :S I didn't know there was an IL-21 and 7...pls explain this question.thanks
0 - ArchivalUser - 05-31-2015
@shayyat18,
Which of the following Risk F for pat disease?
a) Anti Sm Ab
b) Ant centromere Ab
c) HLA-B27 (+)
d) Anti dsDNA Ab
e) HLA-DR4 (+)
0 - ArchivalUser - 05-31-2015
e
eee
0 - ArchivalUser - 05-31-2015
flitamide
0 - ArchivalUser - 05-31-2015
This is Rhem arthritis so the association is HLA DR4 but not sure about the drug. Im going to guess glucocorticoid?
0 - ArchivalUser - 05-31-2015
@penelope Hi! you recall from Ck if methotrexate fail, what spices you add to it?
0 - ArchivalUser - 05-31-2015
lifonamide
0 - ArchivalUser - 05-31-2015
ohhh I was thinking about steroids, tnf inhibitors, DMARDs or rituximab but you can give Tocilizumab which inhibits IL6 .... Idk of which ones inhibit IL21 and 7 though.
0 - ArchivalUser - 05-31-2015
NICE, one more step you are home.
Do you recall, the drug failed or/intolerant to methotrexate that "inhibitor of JAK" family 1,2 & 3? ( originally dev organ allograft rejection)