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regarding drug resistance - mdkhayat - Printable Version +- USMLE Forum - Largest USMLE Community (https://www.usmleforum.com) +-- Forum: USMLE Forum (https://www.usmleforum.com/forumdisplay.php?fid=1) +--- Forum: Step 1 (https://www.usmleforum.com/forumdisplay.php?fid=2) +--- Thread: regarding drug resistance - mdkhayat (/showthread.php?tid=813707) |
regarding drug resistance - mdkhayat - ArchivalUser - 09-05-2015 Actually I am confused ,can anybody tell me where can I read the mechanism of drug resistance? thanks 0 - ArchivalUser - 09-05-2015 hi mdkhayat just remember the mechanism of action every step clearly...i think its given in uworld and first aid is also good ....of course kaplan LN but now no time .. 0 - ArchivalUser - 09-05-2015 try to remember the picture or figures given in first aid that should help 0 - ArchivalUser - 09-05-2015 ok ,I need to know which resistant mechanism for which MO. 0 - ArchivalUser - 09-05-2015 lets start ,please write what you know ,all my friends , 1. Vanco resistant staph aureus : 2.Methicillin resistant staph aureus 3.beta lactamase resistant 4. meropenem resistancy 5.chloramphenicol resistancy 6.macrolid resistancy 7...... please answer what you know and add what other you know thanks 0 - ArchivalUser - 09-05-2015 1.vancomycin resistance to satph.aureus is through transposition van A gene from enterococcus but generally bacteria develop resisitance by altering d-ala-d-ala aminoacid to d-ala-d-lac 0 - ArchivalUser - 09-05-2015 2.MRSA is by structural change in penicillin binding proteins 0 - ArchivalUser - 09-05-2015 3 and 4..carbpenems also same as cephalosporins and penicillins structural change in PBP(transpeptidases) 0 - ArchivalUser - 09-05-2015 5 ..MOA - binds to ribosomal 50s and inhibit peptidyl transferase enzyme right ....resistance is by plasmid encoded acetytransferase inactivates the drug 0 - ArchivalUser - 09-05-2015 6. MARCOLIDES- formation of methyltransferases that alters drug binding sites(methylation of 23 rRNA binding site) |