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+--- Thread: Anything missing w Adrenoceptor Drug Target? - goodman (/showthread.php?tid=843400)
Anything missing w Adrenoceptor Drug Target? - goodman - ArchivalUser - 08-11-2017
MOBILE POOL: Indirect acting sypathomimetics (e.g. amphetamines, ephedrine, tyramine) displace NE , enhancing postjunctional actions.
UPTAKE 1: Inhibited by some Indirect-acting sympathomimetics (e.g. cocaine). Increasing postjunctional actions of NE.
Prejunctional Alpha Receptor (ALPHA 2):Activators (e.g clonidine alpha metyldopa) cause inhibition of tyrosine hydroxylase (↓ NE release from ending)
GRANULAR UPTAKE of NE: Blocker (e.g. reserpine) decrease prejunctional levels of NE available for release.
NE release from Granules: Blocker (e.g guanethidine) decrease postjunctional acions of NE.
Postjunctional Receptors: Activated by many direct-acting sympathomimetics and are also" targets" for antagonist drugs.