07-13-2006, 02:09 AM
One month after undergoing an uneventful renal transplant for chronic renal failure secondary to glomerulonephritis, a 38-year-old woman is hospitalized because of increased serum urea nitrogen (BUN) and Creatinine levels. Prior to transplantation, she had been receiving hemodialysis for 3 years. Current medications include cyclosporine and prednisone. Examination shows no abnormalities. Over the past 48 hours, urine output has remained stable. Both renal biopsy and a radionuclide scan confirm the diagnosis of acute rejection. Which of the following is the most effective treatment?
A) Immediate discontinuation of cyclosporine
B) Increased dosage of corticosteroids
C) Diuresis and alkalinization of the urine
D) Renal dialysis for 1-2 weeks
E) Transplant nephrectomy
A) Immediate discontinuation of cyclosporine
B) Increased dosage of corticosteroids
C) Diuresis and alkalinization of the urine
D) Renal dialysis for 1-2 weeks
E) Transplant nephrectomy