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60 y/o pt. with lymphoma complains of weakness, exertional SOB, easy fatigability, HGb-10, Hct-30, Ret. count -3.5, LDH-400,, + spherocytes, + Coombs test for IgG, most likely DX
1. cold Ab Hemolytic Anemia
2. hereditary sperocytosis
3. autoimmune hemolytic anemia
*4. warm Ab Hemolytic anemia
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In cold ab hemolytic anemia, the hemolysis occurs only when the patient is exposed to a cold environment (or so I think i've read) Since the q doesnt mention anything like that, warm Ab hemolytic an wud be more likely.
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cold antibody anaemia is caused by IgM antibodies and warm by IgG and our patient has IgG antibodies.
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Autoimmune haemolytic anaemia may be due to:
warm reactive IgG autoantibodies
cold reactive IgM autoantibodies / cold haemagglutin disease
drug provoked haemolytic anaemia
complement activating IgG of paroxysmal cold haemoglobinuria