08-07-2006, 12:39 AM
MRL mutant mice are characterised by defect in the fas gene and marked increase in the T lymphocyte accumulation What is the most likely cause of the susceptibility of these mutants to autoimmune disease
1 decreased cell transit time for t lympho
2 decreased dependence on APCs for activation
3 decreased respomse to clonal deletion in the thymus
4 increased responsiveness of mature t lympho to antigenic stimulation
1 decreased cell transit time for t lympho
2 decreased dependence on APCs for activation
3 decreased respomse to clonal deletion in the thymus
4 increased responsiveness of mature t lympho to antigenic stimulation