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Sjögren syndrome - drdeath
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09-01-2006, 05:48 PM
13. A biopsy of an enlarged salivary gland from an individual with Sjögren™s syndrome is most likely to histologically reveal an extensive infiltrate of
a. Basophils b. Eosinophils c. Epithelioid cells d. Lymphocytes e. Neutrophils
09-01-2006, 06:02 PM
The answer is d. Sjögren™s syndrome is characterized
by dryness of the mouth (xerostomia) and eyes (keratoconjunctivitis sicca). Secondary Sjögren™s syndrome is associated with rheumatoid arthritis (RA), SLE, or systemic sclerosis. The primary form shows increased frequency of HLA-DR3, while association with RA shows a positive correlation with HLA-DR4. Anti-SSB antibodies are fairly specific, anti- SSA less so, and both may occur in SLE; rheumatoid factor is often present. Glomerular lesions are very rare, but a mild tubulointerstitial nephritis is quite common and may result in renal tubular acidosis. In addition to the usual dense, lymphoplasmacytic infiltrate of salivary glands, the lymph nodes may show a œpseudolymphomatous appearance. True B cell lymphomas have developed with increased frequency in Sjögren™s syndrome. |
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