kaplan6 - nishi

[ArchivalUser]

A 61-year-old overweight woman complains of weakness, excessive thirst, and increased urination. Lately she has noticed that she is always hungry, but has also been experiencing nausea and vomiting. Review of systems is significant for blurred vision, and frequent vaginal yeast infections. Her blood glucose is 220 mg/dL. She is given an oral antidiabetic medication, but during the next several weeks, the patient develops shortness of breath and ankle edema. Which of the following medications was most likely prescribed?
A. Acarbose
B. Glimepiride
C. Metformin
D. Repaglinide
E. Rosiglitazone

[ArchivalUser]

c...?/

[ArchivalUser]

E??

[ArchivalUser]

e??

[ArchivalUser]

E is the answer.....Thiazolidinediones (pioglitazone and rosiglitazone) reduce insulin resistance, improve plasma cholesterol levels, and reduce risk for blood clots. Rosiglitazone is an oral antidiabetic that acts primarily by increasing insulin sensitivity. The drug improves glycemic control while reducing circulating insulin levels.

Patients who are on rosiglitazone therapy should be observed for signs and symptoms of heart failure, and the drug should be discontinued immediately if any deterioration in cardiac status occurs.
careful monitoring of serum transaminase levels is essential. Rosiglitazone can also cause ovulation to resume in premenopausal anovulatory women.