09-18-2006, 11:33 PM
bone morphogenic factor=extra osseous bone formation(Ectopic ossification is the abnormal formation of bone within extraskeletal soft tissues. )
fibroblast growth factor=amelia (total absence of a limb) because the limb bud AER failed to express FGF
syndactyly caused by failure of apoptosis between the digital rays may result from disruption of expression of Bone morphogenetic substance.
WNT gene factor=function
ROBABLE DEVELOPMENTAL PROTEIN. SIGNALING BY WNT-7A ALLOWS SEXUALLY DIMORPHIC DEVELOPMENT OF THE MULLERIAN DUCTS.
disease: MALE MICE LACKING WNT-7A FAIL TO UNDERGO REGRESSION OF THE MULLERIAN DUCT AS A RESULT OF THE ABSENCE OF THE RECEPTOR FOR MULLERIAN-INHIBITING SUBSTANCE. WNT7A-DEFICIENT FEMALES ARE INFERTILE BECAUSE OF ABNORMAL DEVELOPMENT OF THE OVIDUCT AND UTERUS, BOTH OF WHICH ARE MULLERIAN DUCT DERIVATIVES.
prominent involvement of LIM-homeodomain proteins in tissue patterning and differentiation, and their function in neural patterning is evident in all organisms studied to date.LIM homeodomain transcription factors regulate the development of the proper topology of motor neuron subtypes in the vertebrate spinal cord by coordinately controlling cell migration and axon guidance.
Hox genes function in patterning the body axis. Thus, by providing the identity of particular body regions, Hox genes determine where limbs and other body segments will grow in a developing fetus.Mutations in any one of these genes can lead to the growth of extra, typically non-functional body parts in invertebrates
fibroblast growth factor=amelia (total absence of a limb) because the limb bud AER failed to express FGF
syndactyly caused by failure of apoptosis between the digital rays may result from disruption of expression of Bone morphogenetic substance.
WNT gene factor=function
ROBABLE DEVELOPMENTAL PROTEIN. SIGNALING BY WNT-7A ALLOWS SEXUALLY DIMORPHIC DEVELOPMENT OF THE MULLERIAN DUCTS.disease: MALE MICE LACKING WNT-7A FAIL TO UNDERGO REGRESSION OF THE MULLERIAN DUCT AS A RESULT OF THE ABSENCE OF THE RECEPTOR FOR MULLERIAN-INHIBITING SUBSTANCE. WNT7A-DEFICIENT FEMALES ARE INFERTILE BECAUSE OF ABNORMAL DEVELOPMENT OF THE OVIDUCT AND UTERUS, BOTH OF WHICH ARE MULLERIAN DUCT DERIVATIVES.
prominent involvement of LIM-homeodomain proteins in tissue patterning and differentiation, and their function in neural patterning is evident in all organisms studied to date.LIM homeodomain transcription factors regulate the development of the proper topology of motor neuron subtypes in the vertebrate spinal cord by coordinately controlling cell migration and axon guidance.
Hox genes function in patterning the body axis. Thus, by providing the identity of particular body regions, Hox genes determine where limbs and other body segments will grow in a developing fetus.Mutations in any one of these genes can lead to the growth of extra, typically non-functional body parts in invertebrates