neuro23 - nishi

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A 33-year-old female patient treated with haloperidol for a history of
schizophrenia is seen in the ED because of complaints of fever, stiffness,
and tremor. Her temperature is 104°F, and her serum creatine kinase (CK)
level is elevated. What has occurred?
a. Overdose
b. Allergy
c. Neuroleptic malignant syndrome (NMS)
d. Tardive Dyskinesia
e. Parkinsonism

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Neuroleptic malignant
syndrome is thought to be a severe form of an extrapyramidal
syndrome that can occur at any time with any dose of a neuroleptic
agent. However, the risk is higher when high-potency agents are used in
high doses, especially if given parenterally. Mortality from NMS is greater
than 10%.