02-03-2007, 02:25 PM
A 3-month-old boy presents with poor feeding and growth, low
muscle tone (hypotonia), elevation of blood lactic acid (lactic acidemia),
and mild acidosis (blood pH 7.3 to 7.35). The ratio of pyruvate to lactate
in serum is elevated, and there is decreased conversion of pyruvate to
acetyl coenzyme A in fibroblasts. Which of the following compounds
might be considered for therapy?
a. Pyridoxine
b. Thiamine
c. Free fatty acids
d. Biotin
e. Ascorbic acid
muscle tone (hypotonia), elevation of blood lactic acid (lactic acidemia),
and mild acidosis (blood pH 7.3 to 7.35). The ratio of pyruvate to lactate
in serum is elevated, and there is decreased conversion of pyruvate to
acetyl coenzyme A in fibroblasts. Which of the following compounds
might be considered for therapy?
a. Pyridoxine
b. Thiamine
c. Free fatty acids
d. Biotin
e. Ascorbic acid