Malignant hyperthermia - triplehelix

[ArchivalUser]

Succinylcholine and halothane was used to anesthetize a patient, who later developed high fever >1045'F), tachycardia, hypertension and tachypnea.

What is the underlying mechnism of this condition ?

[ArchivalUser]

Some defect in Ca++ channels has been implicated in the cause and thats the reason Dantrolene is used in the treatment.

but the total mechanism is poorly understood

[ArchivalUser]

that choice was not in answer option

[ArchivalUser]

Defect in Ryanodine calcium channels. Causes excessive calcium release, causing excesive muscle contraction, leading to hyperthermia

[ArchivalUser]

i knew this explanation, but none was in answer choices.
This is a Q from Kaplan Q-book medicine, I will have to see the question and will get back later.