03-24-2007, 02:47 AM
A 18-year-old man presents for a health maintenance examination. He has a family history of Tangier disease, and a number of adults in his family have either hepatosplenomegaly, recurrent polyneuropathy, or both. Which of the following would be the strongest finding on physical examination to suggest the presence of this disease?
A. Angiokeratomas
B. Grey-brown pigmentation of the forehead, hands, and pre-tibial region
C. Irregular black deposits of clumped pigment in the peripheral retina
D. Orange-yellow tonsillar hyperplasia
E. Pingueculae
A. Angiokeratomas
B. Grey-brown pigmentation of the forehead, hands, and pre-tibial region
C. Irregular black deposits of clumped pigment in the peripheral retina
D. Orange-yellow tonsillar hyperplasia
E. Pingueculae