female with Down's syndrome mosaicism - saonew
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female with Down's syndrome mosaicism - saonew
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03-27-2007, 02:59 PM
Which of the following is the proper cytogenetic notation for a female with Down's syndrome mosaicism?
A. 46,XX,+21/46,XY B. 47,XY,+21 C. 47,XXX/46,XX D. 47,XX,+21/46,XX E. 47,XX,+21(46,XX)
03-27-2007, 05:21 PM
quansar there is a / in D and ( ) in E
but y is the answer D, elaborate please
03-27-2007, 08:11 PM
The answer is: D
Mosaicism occurs when a chromosomal anomaly affects one of several precursor cells of an embryo or tissue. The two or more karyotypes that characterize the mosaic cells are separated by a slash in cytogenetic notation. The notation 47,XX,+21 denotes a cell line typical of a female with trisomy 21 (Down's syndrome), while 46,XX is the karyotype expected for a normal female |
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