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safer drug - kabiraj
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03-30-2007, 05:35 AM
Which of the following drugs has the wider margin of safety:
A. Bupropion B. Angiotensin II antagonists C. Phenytoin D. Valproic acid E. Cyclosporine F. Vancomycin
03-30-2007, 06:58 AM
am not sure.... but does cause Seizures in Higher doses .... not Very Uncommon
may be b???
03-30-2007, 07:37 AM
Bupropion entered the market in 1984 with a recommended doasage of 400-600 mg and in 1986 was removed from the market because of significant incidence of seizures. The drug renentered the market in 1989 with the maximal recomd dosage range of 100-400 mg (max 450), which significantly dropped the incidence of seizures from 2% to 0.1-0.2%!!!. So, needless to say that bupropion has a very narrow margin of safety! The correct answer is B.
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