h.mole - pinkypossible

[ArchivalUser]

in Hydratidiform mole46XY , how much maternal and how much paternal contribution is present?

[ArchivalUser]

anybody knows?

[ArchivalUser]

in case of complete moles paternal :maternal ratio is 2:1.usually moles r 46 XX...infrequently maybe 46 XY ..

[ArchivalUser]

hydatyform mole can be complete and partial, complete moleis 46xxand is purely paternal in origin, no maernal chromosomes. Partial mole is commonly triploid or tetraploid.
hope it helps.

[ArchivalUser]

thanks a lot guys.....
Complete mole is the most common type.
-The entire placenta is neoplastic.
-Dilated, swollen villi without fetal blood vessels (Fig. 21-13)
-No embryo is present.
-46XX (90% of cases)
-Both chromosomes are of male origin.
-Egg is fertilized by two haploid spermatozoa with X chromosomes.
-Increased risk for developing choriocarcinoma
Clinical findings
-Preeclampsia develops in the first trimester
-Uterus is too large for gestational age
-Increased hCG for the gestational age
-"Snowstorm appearance" with ultrasound
Partial mole
-Not all villi are neoplastic or dilated.
-Embryo is present.
-Triploid (69XXY)
-Egg with 23X is fertilized by a 23X and a 23Y sperm.
-No increased risk for developing a choriocarcinoma