06-30-2007, 09:38 AM
A 35-year-old woman at 18 weeks' gestation has an increased serum α-fetoprotein concentration. Which of the following has the greatest influence in determining the predictive value of this test for neural tube defects?
A) Concentration of α-fetoprotein in maternal serum
B) Maternal history of monozygotic twin pregnancies
C) Prevalence of neural tube defects in the population in question
D) Sensitivity of the test
E) Specificity of the test
A) Concentration of α-fetoprotein in maternal serum
B) Maternal history of monozygotic twin pregnancies
C) Prevalence of neural tube defects in the population in question
D) Sensitivity of the test
E) Specificity of the test