difference b/n neuroleptic syndrome and serotonin - trazomle

[ArchivalUser]

guys tell the difference between neuroleptic and serotonin syndrome? dont refer to books?

[ArchivalUser]

there r three hyperthermic syndromes:
all have HYPERTHERMIA and HYPERTENSION
1.SEROTININ SYNDROME: SSRIs,MAOI,Linezolid can b the cause.
There is hyperreflexia,clonus+icreased bowel sounds,diarrhea+agitation, ONSET WITHIN HOURS. t/m Sedation(benzodiazepines)
2.Neuroleptic Malignant: d2 blocking antipsychotics
There is PARKINSONISM acute + nl or reduced bowel movement. ONSET 1-3DAYS. t/m Diphenhydaramine
3.Malignant Hyperthermia: volatile anesthetics ONSET WITHIN MTS. t/m Dantrolene
And of course look for the clue in history

[ArchivalUser]

you r right what i thought it as

neurolept malignant -- hyperthermia , hypertension, muscle rigidity

where as SEROTONIN SYNDROME will have in addition to all above will have hyperreflexia , seizures .
correct me if i am wrong

[ArchivalUser]

The Serotonin syndrome has the triad:
Cognitive effects: mental confusion, hypomania, hallucinations, agitation, headache, coma.
Autonomic effects: shivering, sweating, fever, hypertension, tachycardia, nausea, diarrhea.
Somatic effects: myoclonus/clonus, hyperreflexia, tremor.
And there are a recent addition or increase in dose of an agent that raises serotonin levels
The MNS have similar symptoms, but it occurs from prolonged use f neuroleptics or withdrawal of dopamine agonists, and has muscle rigidity, in contrast to myoclonus or hyperreflexia with SD.

[ArchivalUser]

Ok lemmie follow this by asking the MOA of the drug used to treat the hypothermia?

This was a Step 1 question a few months ago and was on our Pharm shelf as well.

I'll post it later if nobody gets it.

[ArchivalUser]

do u mean hyPERthermia??thats dantrolene

[ArchivalUser]

yes Dantrolene hyperthermia...oops typo before!!