Team august july 4th - pawan

[ArchivalUser]

cancer epidemology
male prostate . female : breast
lung lung
mortality: in both sex lung

[ArchivalUser]

target cells: HbC disease, asplenia, liver disease, thalasemia

could someone tell me abt HbC disease plz

[ArchivalUser]

pawan, goljan audios are mp2, they must be converted to mp3 before you can hear them on ipod
you can use any free converter
search on download.com for any mp2 to mp3 converter that is easy to use

[ArchivalUser]

HbC is a substitution of lysine for glutamate in the 6th position of beta globin chain
because the substituted amino acid is lysine which is not hydrophobic (unlike valine in HbS), the hemoglobin does not aggregate, and there is only a mild hemolytic anemia
it travels slower than HbS and HbA towards the cathode, because lysine is positively charged, wheras valine is uncharged, and glutamate is negatively charged

[ArchivalUser]

thanks fhelou
Cheers !

hb c disease it is also dt substitution of aa
namely lysine for glutamine