reproductive path - droperidol

[ArchivalUser]

Any ideas?

A 32-year-old male presents to primary care clinic with a painless testicular mass. On examination, the mass does not transilluminate. A scrotal ultrasound shows a hypoechoic mass in the left testicle. Placental alkaline phosphatase (PLAP) is elevated. A testicular biopsy shows nests of cells with clear cytoplasm and centrally located nuclei. There are prominent nucleoli. The nests are separated by fibrous septa. From the list below, which of the following histological findings is commonly seen with this type of tumor?
a. Schiller-Duvall bodies
b. Lymphocytic infiltrate
c. Extensive fibrosis with a small focus of primary tumor
d. Syncytiotrophoblasts surrounding cytotrophoblasts forming
primitive placental villi
e. Call-Exner bodies


i got this one from the link for smashstep1

[ArchivalUser]

a?

[ArchivalUser]

bb

[ArchivalUser]

b b b

[ArchivalUser]

its B . please refere to that link
http://library.med.utah.edu/WebPath/MALE...LE096.html

Thanks to Zka

[ArchivalUser]

good work!


Choice (B) is the correct answer. Seminomas are germ cell tumors that originate from the germinal epithelium of the seminiferous tubules. Testicular tumors typically present as a painless testicular mass that does not transilluminate. Scrotal ultrasound shows a hypoechoic mass. Grossly, seminomas are characterized by a tan to yellow cut surface without hemorrhage or necrosis. Histologically, seminomas are characterized by nests of tumor cells with clear cytoplasm and centrally located nuclei with prominent nucleoli. The nests of tumor cells are separated by fibrous septa with a lymphocytic infiltrate. 10% of patients with seminomas have an elevated human chorionic gonadotropin. Most seminomas have an elevated serum placental alkaline phosphatase (PLAP). An elevated lactate dehydrogenase (LDH) may be seen with germ cell tumors and reflects tumor burden. Schiller-Duvall bodies (Choice A) are seen with yolk sac tumors and are characterized by a central vessel surrounded by cuboid to columnar tumor cells. Schiller-Duvall bodies may resemble primitive glomeruli. Extensive fibrosis with a small focus of primary tumor (Choice C) is associated with testicular chorionic carcinoma. Testicular choriocarcinoma is a rare, aggressive testicular tumor that may rapidly outgrow its blood supply resulting in hemorrhage and necrosis. The tumor may become fibrotic with only a small area of primary tumor with extensive distant metastases. Syncytiotrophoblasts surrounding cytotrophoblasts forming primitive placental villi (Choice D) are also associated with testicular choriocarcinoma. Call-Exner bodies (Choice E) are associated with granulosa cell tumors and are characterized by granulosa cells with coffee-bean nuclei surrounding eosinophilic proteinaceous material.