08-10-2007, 06:25 AM
WHEN DOES 'CORTISOL' CAN ACT AS 'ALDOSTERONE' ?
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physio endo - drhimanshu
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08-10-2007, 06:45 AM
drug hydrocotisone has glucocorticoid as well mineralocorticoid action,read somewhere.is that so.
08-10-2007, 06:50 AM
HINT:- ALDOSTERONE AND CORTISOL HAVE ALMOST SIMILAR STRUCTURE , AS SUCH CORTISOL CAN ACT DIRECTLY ON COLLECTING DUCTS AND CAN FUNTION AS ALDOSTERONE THERE
BUT ,,,,,NORMALY IT DOES NOT DO THIS COZ IT GETS INACTIVATED BY AN ENZYME CALLED "11-beta-hydroxysteroid dehydrogenase" .........
08-10-2007, 06:51 AM
hi
In hypercorticolism due to its intrinsic mineralocorticoid effects producing hypokalemic metabolic alkalosis. just guessing , pls correct me if iam wrong
08-10-2007, 07:01 AM
OK THIS IS TRUE .....DUE TO MINERALOCORTIOD ACTIVITY , IS HYPERCORTICOLISM THRE WILL BE EXCESS SECRETION OF K+ AS WELL AS H+ PRODUCINS "HYPOKALEMIC METABOLIC ALKALOSIS"
BUT WOT U R TALKIN IS A CONDITION WEN THERE'S EXCESS CORTISOL AND WOT IM ASKING IS A NORMAL CONDION . ANOTHER HINT :- IT HAS TO BE SOMETHING THAT INHIBITS "11-BETA-HYDROXYSTEROID DEHYDROGENASE" |
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