Topic# 08. Autoimmune diseases-HY Facts ! - oom

[ArchivalUser]

1.SLE:
+ANA>95%
+Anti Ds DNA: 40%-60% cases ---Specific
+Anti Sm: 20-30%----Specific

-type ll and lll Hypersensitivity rkn
-loss of self tolerance and production of auto antibodies

clinical: hemolytic anemia, thrombocytopenia,leukopenia
- libman-Sacs endocarditis


2. Sjogren Sydr:
-destruction of lacrimal and salivary glands
- +Antiribonucleoprotein Ab, viz: Anti-SS-A(Ro) and Anti-SS-B(La)

Clinical: Mikuliz Sydr
-high rish of lymphoma

3.Scleroderma:
cause: increased fibroblast by GF and cytokines
Types:
1. Diffuse:
+Anti-DNA topoisomeras l antibodies(Scl-70)
+Raynaud phenomenon
2.Limited= CREST :
+Anticentromere Ab


pls add on more facts!