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hy 1 - guest1
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#1
09-08-2007, 04:56 AM
Transgenic mouse with defect in B2 microglobulin gene. What is the immuno defect?
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#2
09-08-2007, 05:02 AM
MHC classI ?
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#3
09-08-2007, 05:18 AM
The B2 microglobin is part of the MHC Class I molecule. So, a defect here will cause a problem with CD8 + cells so cell mediated immunity is crushed!
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